"Blues Run The Game" Is A 1965 Song By The American Singer-Songwriter Jackson C. Frank. The Song Was The Opening Track On His Self-Titled Debut Album. The Song Has Been Covered By Numerous Other Artists Including Simon & Garfunkel Sandy Denny Nick Drake Bert Jansch Counting Crows John Mayer Colin Meloy Robin Pecknold Mark Lanegan Laura Marling Jack Steadman Martin Simpson And Others.